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Weight loss, malabsorption, and steatorrhea are related to the advanced stages of exocrine destruction, and brittle diabetes becomes a destructive sequela of the loss of endocrine function [13]

Pastore A, Noce A, Di Giovamberardino G, De Stefano A, Calla C, Zenobi R,

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As an extracellular copper-dependent monoamine oxidase, Lysyl oxidase (LOX) catalyzes the crosslinking of collagen and elastin proteins into insoluble mature fibers to contribute tensile strength of collagen fiber and elasticity of elastin fiber 15,16,34,36,37,38